||Indian Kino tree
has a long history of use in India as a treatment for diabetes.
Pterocarpus bark is a rich source of polyphenolic compounds that are
reported to have blood sugar lowering effects in laboratory studies. It
is one among the best hypoglycemic agent. Tests on mice and rabbits with
alcohol and aqueous extracts of this plant have showed hypoglycemic
action, probably by hindering the absorption of glucose in the
activity of various subfractions of the alcohol extract of the bark of
Pterocarpus marsupium Roxb. was evaluated in alloxan-induced diabetic
rats. It is found that extract of Pterocarpus marsupium exhibits
significant antidiabetic activity and corrects the metabolic alterations
in diabetic rats and this activity may resemble insulin-like properties.
extract of P. marsupium at both doses, i.e., 100 and 200 mg/kg, decreased
the fasting and postprandial blood glucose in type 2 diabetic rats. The
200 mg/kg had more pronounced effect on postprandial hyperglycemia. The
drug also improved the body weight of diabetic animals. Cytokine TNF-α was
found to be elevated in untreated diabetic rats due to chronic systemic
inflammation. The aqueous extract at both doses significantly (P < 0.001)
decreased the elevated TNF-α level in type 2 diabetic rats.