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  Latin Name Phyllanthus urinaria; Phyllanthus niruri
English Name Phyllanthus; Grape weed; Shatter stone
Hindi Name Bhuiamala; Bhumyamalaki
Part Used Whole Plant

1Phyllanthus niruri is a bitter herb and reported to possess astringent, deobstruent, stomachic, diuretic, febrifugal and antiseptic properties. It is used in stomach troubles such as dyspepsia, colic, diarrhea and dysentery, and is also employed in urino-genital system.

2An aqueous extract of the plant Phyllanthus niruri inhibits endogenous DNA polymerase of hepatitis B virus and binds to the surface antigen of hepatitis B virus in vitro. The extract also inhibits woodchuck hepatitis virus (WHV) DNA polymerase and binds to the surface antigen of WHV in vitro.

3Phyllanthus niruri is a plant that has been shown to interfere in the growth and aggregation of calcium oxalate (CaOx) crystals. In the present study we evaluated the effect of Phyllanthus niruri on the preformed calculus induced by introduction of a CaOx seed into the bladder of male Wistar rats. Phyllanthus niruri treatment (5 mg/ rat/day) was initiated immediately or 30 days after CaOx seeding and thus in the presence of a preformed calculus. The resulting calculi were weighed and analyzed by X-ray diffraction, stereomicroscopy and scanning electronic microscopy. Precocious Phyllanthus niruri treatment reduced the number (75%, P < 0.05) and the weight (65%, P < 0.05) of calculi that frequently exhibited a matrix-like material on its surface, compared to the untreated CaOx group. In contrast, Phyllanthus niruri treatment in the presence of a preformed calculus did not prevent further calculus growth; rather, it caused an impressive modification in its appearance and texture.

Calculi from Phyllanthus niruri-treated animals had a smoother, homogeneous surface compared to the spicule shape of calculi found in the untreated CaOx group. Results suggest that Phyllanthus niruri may have a therapeutic potential, since it was able to modify the shape and texture of calculi to a smoother and probably more fragile form, which could contribute to elimination and/or dissolution of calculi.


References:

 

1. The Wealth of India, Raw materials, Vol-8: Ph-Re, edition-2005, Page-34
2. PMID: 3467354, Proc Natl Acad Sci U S A. 1987 Jan;84(1):274-8.
3. PMID: 16896689, Urol Res. 2006 Dec;34(6):351-7.


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