small tree or shrub with spinescent branches. The plant gum resin has
been used in Ayurvedic for centuries in the treatment of a variety of
disorders, most notably in inflammations, Arthritis, tumors, thyroid
dysfunctions and as a lipid lowering agent.
extract of the resin of Guggul showed anti-inflammatory activity. The
neutral fraction of ethyl acetate extract of resin showed
hypocholesterolemic activity while the acidic fraction showed
anti-inflammatory activity. It is also used in the treatments of swelling
like Galganda-Granthi etc.
is a bioactive constituent of resinous sap originating from the Guggul
tree, which has been used over several thousands of years to treat various
diseases, including atherosclerosis, rheumatism, and obesity.
Guggulsterone has inhibitory effect on TNF-α expression and COX-2
production and it may be mediated through its inhibition of nuclear
factor-kB activation. Our findings provide an insight into the molecular
mechanisms underlying the anti-inflammatory activities of guggulsterone.
extract has showed antihyperglycemic and antioxidant activities in
streptozotocin induced diabetic rats. 5It is also found
effective in regulating hypothyroidism was in female mice.
mukul inhibits the growth of human prostate cancer cells by causing
apoptosis. The study reveals that z-guggulsterone inhibits angiogenesis by
suppressing the VEGF-VEGF-R2-Akt signaling axis. Together, our results
provide compelling rationale for further preclinical and clinical
investigation of z-guggulsterone for its efficacy against prostate cancer.