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  Latin Name Commiphora mukul
English Name Indian Bedellium
Hindi Name Guggul
Part Used Exudate

1It is small tree or shrub with spinescent branches. The plant gum resin has been used in Ayurvedic for centuries in the treatment of a variety of disorders, most notably in inflammations, Arthritis, tumors, thyroid dysfunctions and as a lipid lowering agent.

2The aqueous extract of the resin of Guggul showed anti-inflammatory activity. The neutral fraction of ethyl acetate extract of resin showed hypocholesterolemic activity while the acidic fraction showed anti-inflammatory activity. It is also used in the treatments of swelling like Galganda-Granthi etc.

3Guggulsterone is a bioactive constituent of resinous sap originating from the Guggul tree, which has been used over several thousands of years to treat various diseases, including atherosclerosis, rheumatism, and obesity. Guggulsterone has inhibitory effect on TNF-α expression and COX-2 production and it may be mediated through its inhibition of nuclear factor-kB activation. Our findings provide an insight into the molecular mechanisms underlying the anti-inflammatory activities of guggulsterone.

4Guggul extract has showed antihyperglycemic and antioxidant activities in streptozotocin induced diabetic rats. 5It is also found effective in regulating hypothyroidism was in female mice.

6Commiphora mukul inhibits the growth of human prostate cancer cells by causing apoptosis. The study reveals that z-guggulsterone inhibits angiogenesis by suppressing the VEGF-VEGF-R2-Akt signaling axis. Together, our results provide compelling rationale for further preclinical and clinical investigation of z-guggulsterone for its efficacy against prostate cancer.


References:

 

1. Database on medicinal plants, CCFRAS, Dept. of ISM & H, Ministry of Health and Family Welfare Govt. of India, Vol-2, Page-223-228
2. The Wealth of India, First supplementseries (Raw Materials),Vol-2:Cl-Cy,edition,2004,page-162-163
3. PMID: 20971513, Int J Pediatr Otorhinolaryngol. 2010 Dec;74(12):1384-7. Epub 2010 Oct 23.
4. PMID: 21767936, Pathophysiology. 2011 Sep;18(4):255-61. Epub 2011 Jul 20.
5. PMID: 15798994, Phytother Res. 2005 Jan;19(1):78-80.
6. PMID: 18202020, Mol Cancer Ther. 2008 Jan;7(1):171-80.


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