Gotu kola is
prostrate, stoloniferous, perennial herbs, rooting at the nodes. Leaves
are orbicular-reniform, crenate-dentate, base cordate and often lobed,
long petioled. It is found through India up to an altitude of 600 meter.
Gotu Kola is a well known Medhya herb used in Ayurveda.
extract of Gotukola contains the active molecules – Asiaticosides.
It inhibits iPLA2 (Ca(2+)-independent Phospholipase A2) and
cPLA2 (cytosolic PLA2) activities in cerebellum which is useful to
treat conditions associated with increased PLA(2) activity in the brain
such as epilepsy, stroke, multiple sclerosis and other neuropsychiatric
disorders. 2Researches on Gotukola showed a significant
increase in the dendritic length (intersections) and dendritic branching
points along the length of both apical and basal dendrites.
described here was carried out to investigate the anticonvulsant effect
of different extracts of Centella asiatica with respect to cholinergic
activity on pentylenetetrazol (PTZ)-induced seizures. Findings suggest
that Gotu kola causes perceptible changes in the cholinergic system as one
of the facets of its anticonvulsant activity.
4Gotu kola is
good for nourishing the brain tissues. It is enriched with bioflavonoids
and triterpenes and selenium, reported to rejuvenate the cells and promote
physical and mental health. Bioflavonoids are claimed to be exert
antimutagenic, neurotrophic and xenobiotics ameliorating and membrane
molecular stabilizing effects. Gotu kola extract has showed protective
antioxidant effect on lead acetate induced changes in oxidative biomarkers
in the central nervous system (CNS).