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  Latin Name Centella asiatica
English Name Gotu kola
Hindi Name Mandookparni
Part Used Whole Plant

Gotu kola is prostrate, stoloniferous, perennial herbs, rooting at the nodes. Leaves are orbicular-reniform, crenate-dentate, base cordate and often lobed, long petioled. It is found through India up to an altitude of 600 meter. Gotu Kola is a well known Medhya herb used in Ayurveda.

1Concentrated extract of Gotukola contains the active molecules Asiaticosides. It inhibits iPLA2 (Ca(2+)-independent Phospholipase A2) and cPLA2 (cytosolic PLA2) activities in cerebellum which is useful to treat conditions associated with increased PLA(2) activity in the brain such as epilepsy, stroke, multiple sclerosis and other neuropsychiatric disorders. 2Researches on Gotukola showed a significant increase in the dendritic length (intersections) and dendritic branching points along the length of both apical and basal dendrites.

3The study described here was carried out to investigate the anticonvulsant effect of different extracts of Centella asiatica with respect to cholinergic activity on pentylenetetrazol (PTZ)-induced seizures. Findings suggest that Gotu kola causes perceptible changes in the cholinergic system as one of the facets of its anticonvulsant activity.

4Gotu kola is good for nourishing the brain tissues. It is enriched with bioflavonoids and triterpenes and selenium, reported to rejuvenate the cells and promote physical and mental health. Bioflavonoids are claimed to be exert antimutagenic, neurotrophic and xenobiotics ameliorating and membrane molecular stabilizing effects. Gotu kola extract has showed protective antioxidant effect on lead acetate induced changes in oxidative biomarkers in the central nervous system (CNS).


References:

 

1. PMID: 18455381, Phytomedicine. 2008 Oct;15(10):896-900.
2. PMID: 18218554, J Chin Med Assoc. 2008 Jan;71(1):6-13.
3. PMID: 20144879, Epilepsy Behav. 2010 Mar;17(3):332-5. Epub 2010 Feb 9.
4. PMID: 19025005, Med J Malaysia. 2008 Jul;63 Suppl A:102.


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